Publications

vom Saal, F.S., Nagel, S.C., Palanza, P., Boechler, M., Parmigiani, S. and Welshons, W.V. 1995. Estrogenic pesticides: binding relative to estradiol in MCF-7 cells and effects of exposure during fetal life on subsequent territorial behavior in male mice. Toxicology Letters 77: 343-350. [ abstract ]

Nagel, S.C., vom Saal, F.S., Thayer, K.A., Dhar, M.G., Boechler, M., and Welshons, W.V. 1997. Relative binding affinity-serum modified access assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environmental Health Perspectives 105(1): 70-76.

vom Saal, F.S., Timms, B.G., Montano, M.M., Palanza, P., Thayer, K.A., Nagel, S.C., Dhar, M.G., Ganjam, V.K., Parmigiani, S. and Welshons, W.V. 1997. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proceedings of the National Academy of Sciences (USA) 94: 2056-2061. [ abstract ]

Nagel, S.C., vom Saal, F.S., and Welshons, W.V. 1998. The effective free fraction of estradiol and xenoestrogens in human serum measured by whole cell uptake assays: physiology of delivery modifies estrogenic activity. Proceedings of the Society for Experimental Biology and Medicine 217: 300-309. [ abstract ]

vom Saal, F.S., Cooke, P.S., Buchanan, D.L., Palanza, P., Thayer, K.A., Nagel, S.C., Parmigiani, S., and Welshons, W.V. 1998. A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior. Toxicology and Industrial Health 14(1/2): 239-260.

Welshons, W.V., Nagel, S.C., Thayer, K.T., Judy, B.M., and vom Saal, F.S. 1999. Low-dose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate weight. Toxicology and Industrial Health 15(1-2): 12-25.

Nagel, S.C., vom Saal, F.S., and Welshons, W.V. 1999. Developmental effects of estrogenic chemicals are predicted by an in vitro assay incorporating modification of cell uptake by serum. Journal of Steroid Biochemistry and Molecular Biology 69: 343-357. [ abstract ]

Wijayaratne, A.L., Nagel, S.C., Paige, L.A., Christensen, D.J., Norris, J.D., Fowlkes, D.M., and McDonnell, D.P. 1999. Comparative analysis of mechanistic differences among antiestrogens. Endocrinology 140 (12): 5828-5840. [ abstract ]

Nagel, S.C., Hagelbarger, J.L., and McDonnell, D.P. 2001. Development of an ER action indicator mouse for the study of estrogens, selective ER Modulators, and xenobiotics. Endocrinology 142 (11):4721-4728. [ abstract ]

Sathya, G., Jansen, M.S., Nagel, S.C., Cook, C.E. and McDonnell, D.P., 2002. Identification and characterization of novel ER?-sparing antiprogestins. Endocrinology 143 (8): 3017-3082. [ abstract ]

Jansen, M.S., Nagel , S.C., Miranda, P.J., Lobenhofer, E.K., Afshari, C.A. and McDonnell, D.P., 2004. Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proceedings of the National Academy of Sciences ( USA), 101(18): 7199-204.

Vom Saal FS, Richter CA, Ruhlen R.R., Nagel S.C., Timms B.G., and Welshons W.V., 2005. The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A. Birth Defects Res A Clin Mol Teratol 73: 140-145.

Abstracts [ top ]

1. Timms, B.G., Welshons, W.V., Nagel, S.C., Petersen, S.L., Peterson, R.E., and vom Saal, F.S., 1994. Prostate morphogenesis correlates with blood estradiol levels in fetal male and female rats. Estrogens in the Environment III: Global Health Implications, ed. J.A. McLachlan and K.S. Korach.
   
   
2. vom Saal, F.S., Palanza, P., Nagel, S.C., Welshons, W.V., Timms, B.G., Peterson, R.E., and Parmigiani, S., 1994. Estrogenic xenobiotics: Binding relative to estradiol in MCF-7 cells and effects on fetal prostate development and postnatal traits. Program of the International Symposium on Human Health and Environment, Salsomaggiore Terme, Italy.
   
   
3. Nagel, S.C., Taylor, J.A., vom Saal, F.S., Welshons, W.V., 1995. Relative binding affinity-serum enhanced access assay to predict the estrogenic bioactivity of phytoestrogens and alkylphenols. Program of the 77th Annual Meeting of the Endocrine Society, Endocrinology 136 (Suppl): 227, # P1-457.
   
   
4. Nagel, S.C., Thayer, K.A., Boechler, M., Dhar, M., Morellini, F., Taylor, J.A., vom Saal, F.S. and Welshons, W.V., 1995. An in vitro assay to predict the in vivo activity of environmental estrogens. Program of the 28th Annual Meeting of the Society for the Study of Reproduction, Biology of Reproduction 52 (Suppl 1): 96, # 159.
   
   
5. Nagel, S.C., Thayer, K.A., Dhar, M., Taylor, J.A., vom Saal, F.S. and Welshons, W.V., 1995. The relative binding affinity-serum modified access (RBA-SMA) assay predicts the bioactivity of xenobiotic estrogens. Program of the 3rd International Conference on Phytoestrogens, Little Rock, AR.
   
   
6. Welshons, W.V., Nagel, S.C., Thayer, K.A., Dhar, M., Taylor, J.A., and vom Saal, F.S., 1995. Enhanced estrogenic activity of phytoestrogens and other estrogen xenobiotics in human serum. Program of the Third International Conference on Phytoestrogens, Little Rock, AR.
   
   
7. Nagel, S.C., vom Saal, F.S., Sharpe-Timms, K.L. and Welshons, W.V., 1996. Free estradiol in human cord serum measured at less than 0.05% using saturation analysis. Program of the 10th International Congress of Endocrinology, San Francisco, CA. Endocrinology (Suppl): 227, # P3-401.
   
   
8. Nagel S.C., vom Saal F.S., Welshons W.V., 1997. Free fraction of xenoestrogens in human serum. Program of the 36th Annual Meeting of the Society of Toxicology, Cincinnati, OH. Fundamental and Applied Toxicology 36 (Suppl 1, part 2): 12, #61.
   
   
9. Nagel, S.C., vom Saal, F.S., Sharpe-Timms, K.L., Benson, S.L. and Welshons, W.V., 1997. Mechanisms of fetal vulnerability to xenoestrogens. Program of the Conference on Estrogens in the Environment IV, Arlington, VA, # 13.
   
   
10. Welshons, W.V., Judy, B.M., Nagel, S.C., Taylor, J.A. and vom Saal, F.S., 1997. Estrogen receptor occupancy and response to estradiol and xenoestrogens in MCF-7 cells. Program of the Conference on Estrogens in the Environment IV, Arlington, VA, # 12.
    
    
11. Nagel, S.C., Benson, S.L., vom Saal, F.S., Sharpe-Timms, K.L., and Welshons, W.V., 1998. Species differences in mechanisms of fetal protection from endogenous estrogens. Program of the Xth International Congress on Hormonal Steroids, Quebec City, Canada.
    
    
12. Wijayaratne, A.L., Nagel, S.C., Paige, L.A., Chirstiensen, D.L., Fowlkes, D.M., McDonnell, D.P. 1999. Definition of the mechanistic differences among antiestrogens: Implications for treatment of Breast Cancer. Program of the 81ST Annual Meeting of the Endocrine Society, P3-205.
    
    
13. Nagel, S.C. and McDonnell, D.P. Use of an ERE-lacZ transgenic mouse to assess tissue specificity of estrogens and selective estrogen receptor modulators, presented at "DES Research Update 1999: Current knowledge, future directions," Bethesda, Maryland, July 19, 1999.
    
    
14. Nagel, S.C. and McDonnell, D.P. Use on an ERE-lacZ transgenic mouse to assess tissue specificity of estrogens and selective estrogen receptor modulators. Recent Progress in Hormone Research 55th Conference, Stevenson, Washington, August 7-11, 1999.
    
    
15. Blackwell, K.L., Shan, S., Nagel, S.C., McDonnell, D.P., Broadwater, G., Harris, L., and Dewhirst, M.W. 1999. Tamoxifen inhibits angiogenesis through possible estrogen receptor independent effects on endothelial cells. Program of the 22nd Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 8-11, 1999.
    
    
16. Nagel, S.C. and McDonnell, D.P. 2000. Development of an ERE-Lac Z transgenic mouse to assess tissue specificity of estrogens and selective estrogen receptor modulators. Keystone Symposia: Nuclear Receptors 2000, Steamboat Springs, CO, March 25-31, 2000.
    
    
17. Blackwell, K.L., Nagel, S.C., Snyder, S.A., McDonnell, D.P., and Dewhirst, M.W. Estrogen receptor ligands cause variable levels of cytotoxicity in human endothelial cells that are partially mediated through the induction of apoptosis. American Association for Cancer Research, San Francisco, CA, April 2000.
    
    
18. Welshons, W.V., Nagel, S.C., Judy, B.M., Taylor, J.A., Howdeshell, K.L., Ruhlen, R.L. and vom Saal, F.S. In vitro assessment of endocrine disruptors: Activity of the environmental estrogen bisphenol A at levels of current human exposure. Program of the 2001 Congress on In Vitro Biology, St. Louis, MO, June 10-12, 2001.
    
19. Nagel, S.C., Hagelbarger, J.L., McDonnell, D.P. Development and use of an estrogen receptor action indicator (ERIN) transgenic mouse. Program of the Endocrine Society's 83rd Annual Meeting, Denver, CO, June 19-23, 2001.
    
20. Welshons, W.V., Nagel , S.C., Judy, B.M., Taylor, J.A., Howdeshell, K.L., Ruhlen, R.L. and vom Saal, F.S. In vitro assessment of endocrine disruptors: Activity of the environmental estrogen bisphenol A at levels of current human exposure. Program of the 2001 Congress on In Vitro Biology, St. Louis, MO, June 10-12, 2001.
    
21. Nagel, S.C. , Hagelbarger, J.L., McDonnell, D.P. Development and use of an estrogen receptor action indicator (ERIN) transgenic mouse. Program of the Endocrine Society's 83 rd Annual Meeting, Denver, CO, June 19-23, 2001.
    
22. Jansen, M.S., Nagel , S.C., Lobenhofer, E.K. and McDonnell, D.P. Methoxyacetic acid modulates nuclear receptor activity and alters target gene specificity. Program of the Endocrine Society's 85 th Annual Meeting, Philadelphia, PA, June 19-22, 2003.
    
23. Ghormley, A., Hurrelmeyer, K., Sharpe-Timms, K.L., and Nagel, S.C. Prenatal exposure to xenoestrogens and the development of endometriosis in adulthood. Life Science Undergraduate Research Opportunities Poster Session, University of Missouri-Columbia, July 28, 2005.

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