The University of Missouri provides many effective and efficient research facilities that are available to faculty, staff, and students. The list below is a selection of those most relevant to research on endocrine disruptors.
The Cell and Immunobiology Core Facility provides custom production of monoclonal antibodies, flow cytometric services, and tissue culture reagents. The Core is located in the Medical Sciences Building and is hosted by the Department of Molecular Microbiology and Immunology.
The Proteomics Center provides synthesizes custom peptides, sequences proteins, and provides HPLC and capillary electrophoretic analyses. The core is located in the Christopher S. Bond Life Sciences Center.
The DNA Core provides services in DNA sequencing, DNA fragment analysis, genotyping, genomic variation analysis, and gene expression. The DNA Core also maintains the campus Enzyme Freezer Program, which contains an extensive inventory of restriction enzymes, PCR and qPCR reagents, DNA and RNA purification kits, and various chemicals and biochemicals. Robotic instrumentation also is available for high throughput plasmid isolation, colony picking, and genomic library management. The core is located in the Christopher S. Bond Life Sciences Center and hosted by the Department of Molecular Microbiology and Immunology.
The Molecular Cytology Core is a resource for all types of light microscopy, immunocytochemistry, in situ hybridization techniques, and general scientific image analysis and processing. Instrumentation available for client use includes two confocal microscopes, micro-injection system, epi-fluorescence stereoscope, conventional wide-field microscopes, paraffin microtome, cryostat, and ultramicrotome. The core is located and hosted by the Christopher S. Bond Life Sciences Center.
The Nuclear Magnetic Resonance Core provides equipment maintenance and infrastructure support of research projects that require NMR or for investigators who want to use NMR for structural elucidation and study of chemical and biological reactions. Instrumentation at the Nuclear Magnetic Resonance Core facility includes an 800 MHz NMR spectrometer. The core is located in the Chemistry Building and is hosted by the Molecular Biology Program.
The Electron Microscopy Core supports research that requires scanning or transmission electron microscopy. Services include scanning and transmission electron microscopy, immunoelectron microscopy, x-ray microanalysis, digital imaging and analysis, and preparation of materials and biological specimens. The core is located in the Veterinary Medicine Building and is hosted by the Department of Veterinary Pathobiology.
The Structural Biology Core provides instrumentation and faculty assistance with crystallography, dynamic light scattering, NMR, and peptide synthesis. Researchers who understand the important link between macromolecular structure and function can explore how to get structural information on proteins of interest and which method is best for their needs. The core is located in the Chemistry Building and is hosted by the Molecular Biology Program.
The transgenic Animal Core provides many services, including but not limited to chromosome counting, generation of transgenic mice on FVB and c57BI6 strains using client’s DNA, and genotyping assays. The laboratory facilities include dedicated laboratories for cell culture and micromanipulation. The core is located in the Veterinary Medicine Building and is hosted by the Division of Animal Sciences.
The University of Missouri Bioinformatics Consortium provides an integrated array of high performance computing and communications products and related services to users, including supercomputing-class hardware, software, mass storage systems, file storage areas, consulting services, and training.
The Informatics Research Core Facility serves the bioinformatics needs of researchers at MU. It provides custom web-enabled software development, analysis of high-throughput data, and assembly and annotation of genome-wide sequence data. The core is located in the Bond Life Sciences Center.
Five cores support the Center for Botanical Interaction Studies’ research projects and activities: an administrative core, botanical/plant genomics core, nutrition/animal core, analytical chemistry core, and an interactions core (mega-sequencing/proteomics/informatics/nitrosylation).